
Researchers at Seattle children’s Hospital Research Institute and Fred Hutchison Cancer Research Centre have taken one more step in their fight against cancer by developing a paint that can illuminate cancer cells to help surgeons locate even a single tumor cell.
The paint is a scorpion-derived peptide called chlorotoxin that is linked to the molecular beacon Cy5.5.
Researchers detected a chemical found in large Israeli scorpion venom which is capable of getting attached to cancer cells.
Cy5.5 is a fluorescent molecular beacon that emits photon in the near infrared spectrum. This gives surgeons a much better opportunity to locate and remove all the cancer cells without injuring the surrounding healthy tissues.
This has resolved a major problem regarding the brain tumor where approximately 80% of the malignant cancer recur at the edges of the surgical sites and has a great chance to reappear in the same intensity as before.
Brain is the most complex organ in human body. It has an intercellular filtration system, which allows very few materials to enter into the cells, thus making it difficult for drugs and indicators to enter into the neuron with a rare chance of cure.Cy5.5 can filter through this system easily and illuminates the starting and ending of a tumor.
This technology has resolved the problems and imperfections of methods currently used by surgeons. Cy5.5 is 500 times sensitive than currently used MRI (magnetic reasoning imaging) as it can detect as few as 200 cancer cells which is possible in MRI only if there are more than 1 million cells and still more, it starts adhering to cancer cells within one minute and remains effective for 14 days.
Tumor painting has been successfully tested on mice and has cleared pilot safety test. But this technology still needs to be examined about its toxic effects before seeking approval from food and drugs administration to begin clinical trials.
Image Credit: MIT Press Office and Benjamin A. Teply
Via: medlaunches








